解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::2',4'-dihydroxy-6'-methoxychalcone (cardamonin) is a natural compound with anti-proliferative effects on several cancer types including nasopharyngeal carcinoma. The effects of cardamonin on melanoma cells are unknown. The present study investigated the anti-proliferative effect of cardamonin on human melanoma cell li...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11242
更新日期:2020-02-01 00:00:00
abstract::Chromodomain helicase DNA-binding 5 (CHD5), which is a member of the CHD family, has been identified as a tumor suppressor gene in a variety of malignancies. The aim of the current study was to clarify the clinical significance of CHD5 expression in gastric cancer. CHD5 expression was evaluated using immunohistochemis...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11138
更新日期:2020-01-01 00:00:00
abstract::The purpose of the present study was to evaluate the newest status of patients diagnosed Burkitt lymphoma (BL), an aggressive lymphoma subset with a high cure rate. Furthermore, the study aimed to create prognostic nomograms to consider various prognostic factors and estimate patient survival, paving the way for clini...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11155
更新日期:2020-01-01 00:00:00
abstract::The clinical significance of the proteasome inhibitor MG132 has been examined in numerous human cancer types; however, its influence on the metastasis and progression of pancreatic cancer is yet to be determined. In the present study, the effect of MG132 treatment on pancreatic ductal adenocarcinoma (PDAC) cell lines ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11157
更新日期:2020-01-01 00:00:00
abstract::High mobility group box 1 (HMGB1) is an abundant non-histone nuclear protein that functions as a structural protein of chromatin, regulating genome replication and recombination, mRNA transcription and DNA repair. HMGB1 has been implicated in the tumorigenesis of various cancer types, and the upregulation of HMGB1 has...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11170
更新日期:2020-01-01 00:00:00
abstract::Pancreatic cancer is one of the most lethal cancers. Transmembrane 4 superfamily member 5 protein (TM4SF5) is one of the candidate molecular targets used for the prevention and treatment of TM4SF5-expressing cancers, including hepatocellular carcinoma, colon cancer and pancreatic cancer. Recently, a previous study rep...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11134
更新日期:2020-01-01 00:00:00
abstract::The tumor suppressor protein p53 (TP53) gene is associated with various types of cancer; however, little is known about TP53 expression in patients with childhood acute lymphoblastic leukemia (ALL). The aim of the present study was to investigate the prognostic value of TP53 expression in childhood ALL. To achieve thi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11064
更新日期:2020-01-01 00:00:00
abstract::The long non-coding RNA (lncRNA), RP11-480I12.5 is one of the most dysregulated lncRNAs, which is believed to contribute to the progression of cervical carcinoma (CC); however, the exact function of RP11-480I12.5 in human CC remains unknown. The present study aimed to investigate the function and underlying molecular ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11120
更新日期:2020-01-01 00:00:00
abstract::Lung cancer is one of the most common cancers, which is the leading cause of cancer-related death among various cancers worldwide. Flavokawain A (FKA), a chalcone found in the kava plant, exerts potent anticancer activity. However, the activity and mechanisms of FKA in inhibiting the viability of paclitaxel (PTX)-resi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11069
更新日期:2020-01-01 00:00:00
abstract::Osteosarcoma (OS) is the most common tumor of the musculoskeletal system. Recently, cold atmospheric plasma (CAP) has been regarded as a promising anti-oncogenic therapy. Previous experimental studies have demonstrated that CAP treatment results in significant growth inhibition of human sarcoma and is able to induce a...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11115
更新日期:2020-01-01 00:00:00
abstract::Papillary thyroid carcinoma (PTC) is the most common type of thyroid carcinoma, and its incidence has been on the increase in recent years. However, the molecular mechanism of PTC is unclear and misdiagnosis remains a major issue. Therefore, the present study aimed to investigate this mechanism, and to identify key pr...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11100
更新日期:2020-01-01 00:00:00
abstract::Breast cancer is the most prevalent cancer among women, and diagnosis and treatment represent a substantial challenge due to the lack of adequate molecular targets. It has been shown that long noncoding RNAs (lncRNAs) serve pivotal roles in regulating gene expression in tumors. The roles of long intervening noncoding ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11071
更新日期:2020-01-01 00:00:00
abstract::Breast cancer is the most common malignant tumor in women in the majority of countries, such as China, Britain and Australia, and its morbidity and mortality rates remain very high. Long non-coding RNAs (lncRNAs) are non-coding RNAs (ncRNAs) >200 nucleotides in length that lack open reading frames. LncRNA H19 is a tra...
journal_title:Oncology letters
pub_type: 杂志文章,评审
doi:10.3892/ol.2019.11093
更新日期:2020-01-01 00:00:00
abstract::The upregulation of EPH receptor B4 (EPHB4) results in a survival advantage for tumor cells via the inhibition of the casapse-8-mediated apoptotic pathway, which begins from the cell membrane. The present study investigated the expression patterns of EPHB4, ephrin B2 (EFNB2) and caspase-8 in patients with esophageal s...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11160
更新日期:2020-01-01 00:00:00
abstract::Lonidamine, 6-Diazo-5-oxo-L-norleucine (DON) and orlistat are well known inhibitors of glycolysis, glutaminolysis and of de novo fatty acid synthesis, respectively. Although their antitumor effects have been explored in detail, the potential inhibition of the malignant metabolic phenotype and its influence on the expr...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11008
更新日期:2019-12-01 00:00:00
abstract::Determining the resectable region and volume of the liver prior to anatomical resection is important. The synapse Vincent (SV) system is the current method for surgical liver resection that relies on the surgeon's individual experience and skill. Additionally, in cases involving abnormal liver function, the resectable...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11006
更新日期:2019-12-01 00:00:00
abstract::Increasing evidence has confirmed that long non-coding RNAs (lncRNAs) serve critical roles in the development of a large number of human malignancies, including glioma. Several previously published studies have reported that the lncRNA retinal non-coding RNA3 (RNCR3; also termed LINC00599) exerts important roles in ce...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11002
更新日期:2019-12-01 00:00:00
abstract::Mitotically-associated long non-coding RNA (MANCR) is involved in malignant breast cancer. The present study analyzed the role of MANCR in hepatocellular carcinoma (HCC). MANCR was found to be upregulated in HCC and high expression level of MANCR in cancer tissues predicted poor survival of HCC patients. MicroRNA (miR...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10947
更新日期:2019-12-01 00:00:00
abstract::Primary Ewing's sarcoma (ES) is rare, especially when it occurs in the spinal canal during middle or old age. The rarity of Ewing's sarcoma breakpoint region 1 fusion-negative ES has been reported in the literature. The present case report describes a 60-year-old Chinese patient who was diagnosed with ES originating f...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10958
更新日期:2019-12-01 00:00:00
abstract::Phospholipase C (PLC) is a membrane-associated enzyme that regulates several cellular behaviors including cell motility, growth, transformation and differentiation. PLC is involved in cancer migration, invasion and drug resistance. However, the expression status and prognostic role of PLCB4 in acute myeloid leukemia (...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10921
更新日期:2019-12-01 00:00:00
abstract::Despite advancements in treatment regimens, the mortality rate of patients with oral tongue squamous cell carcinoma (OTSCC) is high. In addition, the signaling pathways and oncoproteins involved in OTSCC progression remain largely unknown. Therefore, the aim of the present study was to identify specific prognostic mar...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10982
更新日期:2019-12-01 00:00:00
abstract::Macrophages are a heterogeneous group of phagocytes that play critical roles in inflammation, infection and tumor growth. Macrophages respond to different environmental factors and are thereby polarized into specialized functional subsets. Although hypoxia is an important environmental factor, its impact on human macr...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10956
更新日期:2019-12-01 00:00:00
abstract::The aim of the present study was to investigate the long non-coding RNA (lncRNA)-microRNA (miRNA)-mRNA regulatory network in gastric cancer (GC) using bioinformatics analysis. Two mRNA gene expression profiles, GSE79973 and GSE54129, and two miRNA expression profiles, GSE93415 and GSE78091, were downloaded from the Ge...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10922
更新日期:2019-12-01 00:00:00
abstract::Gastric cancer (GC) is a malignant tumor that negatively impacts human health, which typically presents in the advanced stages of disease in the majority of patients. Despite the development of combination chemotherapy, only a modest survival advantage is gained in patients with GC treated by this method. Recently, ca...
journal_title:Oncology letters
pub_type: 杂志文章,评审
doi:10.3892/ol.2019.10935
更新日期:2019-12-01 00:00:00
abstract::The mechanisms underlying the pathogenesis of papillary thyroid carcinoma (PTC) have not yet been elucidated. The aim of the current study was to identify potential pathogenic biomarkers in PTC by comprehensively analyzing gene expression and methylation profiles, and to increase the understanding of PTC pathogenesis....
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11059
更新日期:2019-12-01 00:00:00
abstract::Gemcitabine (GCB), which functions via the inhibition of DNA synthesis, is commonly used in the treatment of bladder cancer; however, its response rate is not satisfactory due to the development of drug resistance. The potential for phytochemicals to reverse drug resistance in bladder cancer tumor cells was evaluated....
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11023
更新日期:2019-12-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is generally considered one of the most common gastrointestinal malignant tumors, characterized by high invasiveness and metastatic rate, as well as insidious onset. A relationship between carcinogenicity and aberrant microRNA-139-5p (miR-139-5p) expression has been identified in multipl...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11031
更新日期:2019-12-01 00:00:00
abstract::Colorectal carcinoma (CRC) is a common tumor of the digestive system with poor prognosis. Studies have shown that aberrant microRNA (miRNA) expression can affect CRC progression by regulating target genes. In the present study, we investigated the functional roles and potential mechanisms of miR-331-3p in CRC. The exp...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11029
更新日期:2019-12-01 00:00:00
abstract::Head and neck squamous cell carcinoma (HNSCC), one of the most common malignant tumors, endangers human health. Recently, the incidence of HNSCC has kept increasing: However, its prognosis has not significantly improved. Understanding the molecular mechanism underlying HNSCC development will therefore provide new stra...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10920
更新日期:2019-12-01 00:00:00
abstract::Previous studies have demonstrated that members of the brain-expressed X-linked (BEX) family participate in a wide range of biological functions in normal and tumor tissues. However, their role and clinical significance in lung adenocarcinoma (LUAD) remains unclear. The present study investigated The Cancer Genome Atl...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10905
更新日期:2019-11-01 00:00:00
abstract::The ubiquitin-proteasome pathway is an important protein degradation regulatory system in cells. This pathway is also a reversible process that is strictly regulated, and the regulation of deubiquitinating enzymes (DUBs) represents an important facet of the process. Ovarian tumor-associated proteases domain-containing...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10883
更新日期:2019-11-01 00:00:00
abstract::Factor that binds to the inducer of short transcripts of the human immunodeficiency virus-1 (FBI-1) represents as a crucial gene regulator in colorectal cancer; however, the correlation between FBI-1 and preoperative radiotherapy (RT) in rectal cancer (RC) has not yet been reported. The aim was to detect FBI-1 express...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10890
更新日期:2019-11-01 00:00:00
abstract::Distal-less homeobox 6 antisense RNA 1 (DLX6-AS1) is upregulated in various solid tumors and serves a critical role in the tumorigenesis of cancer. However, to the best of our knowledge, the expression of circulating DLX6-AS1 and its role in the diagnosis of non-small cell lung cancer (NSCLC) have not been previously ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10892
更新日期:2019-11-01 00:00:00
abstract::Scalp angiosarcoma is a rare, extremely aggressive cutaneous malignancy with poor patient prognosis. The present study reviewed the cases of 42 patients who presented scalp angiosarcoma and were treated at the Zhongshan Hospital of Fudan University between January 2002 and December 2013. The clinical characteristics, ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10886
更新日期:2019-11-01 00:00:00
abstract::Chronic hepatitis B virus (HBV) is the leading cause of hepatocellular carcinoma (HCC). Covalently closed circular DNA (cccDNA) is an intermediate in the life cycle of HBV. HBV-encoded X protein (HBx), a key viral oncoprotein, can be specifically ubiquitylated by male specific lethal 2 (MSL2), which causes upregulatio...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10833
更新日期:2019-11-01 00:00:00
abstract::The putative oncogenic role of ATP/GTP binding protein like 2 (AGBL2) in catalyzing α-tubulin detyrosination has recently been characterized in cancer. However, the status of AGBL2 expression in ovarian cancer and its potential clinical and prognostic significance remain unclear. In the present study, immunohistochemi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10829
更新日期:2019-11-01 00:00:00
abstract::Long non-coding RNAs (lncRNAs) govern gene expression by competitively binding to microRNA response elements (MREs). Although they were initially considered as transcriptional noise, lncRNAs have attracted increased attention in oncology. Dysregulation of lncRNAs occurs in various types of human tumor, including esoph...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10808
更新日期:2019-11-01 00:00:00
abstract::Ulcerative colitis (UC) is thought to be associated with precancerous lesions that can ultimately lead to colon cancer. Therefore, diagnostic markers for colorectal dysplasia and cancer are urgently needed for patients with UC. Stathmin 1 (STMN1) is a novel cancer biomarker that is also a novel target for treatment in...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10814
更新日期:2019-11-01 00:00:00
abstract::Non-small cell lung cancer (NSCLC) is the most frequent cancer worldwide with a poor 5-year survival. miR-650 acts as an oncogene and regulates tumor progress in various cancers. Molecular mechanisms of miR-650 in NSCLC cell proliferation and invasion was studied. The mRNA levels of miR-650 and special genes were calc...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10805
更新日期:2019-11-01 00:00:00
abstract::Aldo-keto reductases, known as AKR1C1-AKR1C4 enzymes, are pivotal to NADPH-dependent reduction, and their expression is highly associated with the progression of malignant cancers. However, the expression and distinct prognostic value of the AKR1C family members in liver cancer are not well established. In the current...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10802
更新日期:2019-11-01 00:00:00